Values are generally displayed in milligram per litre. Duis pulvinar non magna ac viverra. The substance identifiers – if available and not claimed confidential – displayed in the ’Substance identity’ section of the Brief Profile are: In addition, information on the type of substance, origin, number and type of registered compositions and other places where the substance is listed are displayed in this section. PKa values of fumaric acid and maleic acids are 3.0-4.5 and 1.5-6.5. Values provided in ppb and Vol% are provided separately. Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). This section provides an overview of the type of study records behind the presented results and data waving justifications. Fumaric acid: Class: Small Molecule: Description: Fumaric acid is a precursor to L-malate in the Krebs tricarboxylic acid cycle. 62, 91301 Forchheim Germany, ARKEMA FRANCE, 420 rue d'Estienne d'Orves 92700 COLOMBES France, OQEMA Contract GmbH, OR1, Nauheimer Strasse 37 70372 Stuttgart Germany, Gas under pressure: refrigerated liquefied gas, Solid: nanomaterial, no surface treatment, Characteristic of sulphur containing compounds, Self-heating substances and mixtures (Cat. pH provides substance information on the substance’s acidity level measured in pH at a temperature measured in °C and a concentration measured in (milli)grams per litre. there is no manual verification or assessment of the correctness of the data. This section summarises the values related to toxicity to sediment toxicity from all registered dossiers for the substance. Note: Registrants can also select ‘other’ as a reaction type for the degradation rate constant of the substance. Flavis number 8.025 . Other relevant information includes the following: To see the full list of notified classifications and have more information on impurities and additives relevant to classification, you can consult the C&L Inventory. Dissociation constant (pKa) at 25 o C : 3.03 : V3 - Note: Weak acid, pka2 = 4.44 : Vapour pressure at 20 o C (mPa) 0.00002 : V3 : Low volatility : Henry's law constant at 25 o C (Pa m 3 mol-1) - - - … In case the substance classification is not harmonised and the substance is not registered the properties are derived from classifications provided in CLP notifications. The Index number is the identification code given to substances in Part 3 of Annex VI to the CLP Regulation ((EC) No 1272/2008). Short–term toxicity to aquatic invertebrates, Long–term toxicity to aquatic invertebrates, Toxicity to aquatic algae and cyanobacteria, Toxicity to aquatic plants other than algae, Endocrine disruptor testing in aquatic vertebrates - in vivo, Toxicity to terrestrial macroorganisms except arthropods. This section summarises the flammability values from all registered dossiers for the substance. When more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. Please note that the information provided in the free-text fields is not published in the brief profiles. Registrants can register their substance’s flammability as: This section summarises the explosiveness values from all registered dossiers for the substance. With protonated fumaric acid k is high, (2.1 ± 0.4) × 109 mol−1 dm3 s−1 due to the nucleophilic character of IP reaction and the electron withdrawing –COOH groups. Pow provides substance information on the partition coefficient type Pow at a temperature measured in °C and acidity in pH. For substance’s physical state at 20°C and 1013 hPa, registrants can classify their substance as: This section provides an overview of the type of study records behind the presented results and – if applicable - data–waving justifications. This section summarises the values related to phototransformation in water from all registered dossiers for the substance. Precautionary measures and guidance on safe use concern the use and handling of the specific substance, not of the presence of the substance in other articles or mixtures. The date of the last update corresponds to the publication date of the Brief Profile and not necessarily to the date in which the update occurred in the source data (registered dossiers, the C&L Inventory or a regulatory process). This section summarises the values related to toxicity to soil macroorganisms (except arthropods) from all registered dossiers for the substance. For this endpoint registrants do not provide summary data. Processable data for study results is prioritised by test species (see list below) and subsequently further prioritised by the dose descriptor. Data is generally displayed in milligrams per kilogram bodyweight per day. If so, the data provided is not processed in the Brief Profile. Displayed are the RANGES of min – max of values (provided in %). In that case, the ATP (Adaptation to Technical Progress) number is displayed. The source of the information is mentioned in the introductory sentence of the hazard statement. EC10 / LC10 or NOEC for microorganisms provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested microorganisms or the no observed effect concentration for microorganisms. Koc provides substance information on the substance’s Koc adsorption at a temperature measured in °C and a percentage of organic carbon. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Results without measurement conditions (pressure) are not processed for the Brief Profile. A substance may have more than one CAS number associated. Biocidal product authorisation – indicates if authorised biocidal products exist which use this substance as an active ingredient. Data is generally displayed in milligrams per litre. The number of studies provided is indicated by ‘[x] studies submitted’, while the actual number of studies processed for the endpoint is indicated by ‘[x] studies processed’. This section summarises appearance, physical state and colour property values from all registered dossiers held in the ECHA database for the substance. The availability of additional data beyond the five results displayed is indicated by (…). This section summarises the values related to toxicity to birds from all registered dossiers for the substance. A distinct classification and labelling corresponds to each Index number. Registrants can register their substance explosiveness as: This section summarises the oxidising values from all registered dossiers for the substance. PNEC STP, data displayed in milligram per litre. This substance is used in the following products: adhesives and sealants, coating products, inks and toners, laboratory chemicals and cosmetics and personal care products. EC10 / LC10 or NOEC for marine sediment provides substance information on the substance’s effect concentration/lethal concentration for 10% of the model organisms feeding off the marine sediment or the no observed effect concentration for of the model organisms feeding off the marine sediment. EC/LC50 for freshwater plants provides substance information on the substance’s effect concentration or lethal concentration for 50% of the freshwater plants in the test, generally displayed in milligram per litre. for charge, stereo–chemical and/or isotopic information. Its chemical formula is HO 2 CCH=CHCO 2 H. Maleic acid is the cis-isomer of butenedioic acid, whereas fumaric acid is the trans-isomer.It is mainly used as a precursor to fumaric acid, and relative to its parent maleic anhydride, maleic acid has few applications. Data is generally displayed in milligrams per kilogram bodyweight per day.Prioritization by test species: See ‘Summary effect on fertility oral route’. The quality and correctness of the information remains the responsibility of the data submitter. This section displays the values related to repeated dose toxicity from all registered dossiers for the substance. Information on the most sensitive study can be provided by the registrants as: Dermal exposure provides information on the substance’s hazard assessment conclusions regarding dermal exposure (for workers). The five highest priority groupings of provided data are displayed in milligram per litre or molar per litre. See information under ‘Applicant’s summary and conclusion – interpretation of results (oral)’. The availability of additional data beyond the five results displayed is indicated by (…). H atm provides substance information on the substance’s Henry’s Law Constant in atm at temperature measured in °C and a pressure measured in Pascal. Registrants can register their substance’s oxidising properties as: Note: Registrants can also select ‘other’ as the oxidising value for their substance. Short-term EC50 or LC50 for terrestrial plants provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of the terrestrial plants in the test, generally displayed in milligram per kilo soil (dry weight). Registrants can choose from the following picklist endpoint conclusions/effect levels: Respiratory irritation provides substance information on the substance’s irritation effect on the respiratory system. Fusce eget lorem sed purus tempus blandit. Values are displayed in milligram per litre. Nat Rev Drug Discov. Maleic acid or cis-butenedioic acid is an organic compound that is a dicarboxylic acid, a molecule with two carboxyl groups. The Hazard classification and labelling section uses the signal word, pictogram(s) and hazard statements of the substance under the harmonised classification and labelling (CLH) as its primary source of information. Since the source data can be updated at any time while the Brief Profiles are updated at intervals, a slight delay in the publication of information may occur. These study results can however be consulted when opening the source data. The aim is to display the lowest values reported as causing the most adverse effects, and hence the broadest possible safety margins for the substance. Vapour pressure provides substance information on the vapour pressure in Pa at a temperature measured in °C. Short-term EC50 or LC50 for soil microorganisms provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of soil microorganisms in the test, generally displayed in milligram per kilo soil (dry weight). This section provides information on suppliers, importers or manufacturers of a substance (active and inactive) that have to register their substance under REACH. Y is the check-digit calculated in accordance with the 10-digit ISBN method. 2000 Jan 1;28(1):235-42. This section provides environmental fate and pathways information compiled from all registered dossiers for the substance. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. This main layer contains sublayers for the chemical formula, atom connections and hydrogen atoms. Displayed is the most conservative of the prioritised value(s). Vivamus mauris lorem, fringilla at diam a, laoreet consequat eros. 110-17-8 Fumaric acid (Fumarate, 2-Butenedioic acid, Trans-Butenedioic acid) is an intermediate in the citric acid cycle used by cells to produce energy in the form of adenosine triphosphate (ATP) from food; also a product of the urea cycle. Data is generally displayed in milligram per litre air. These substances cannot be placed on the market or used after a given date, unless an authorisation is granted for their specific use, or the use is exempted from authorisation. These acids experience two-step dissociation in aqueous solutions.They have the same structural formula but different spatial configurations. This section summarises the values related to toxicity to mammals (other above-ground organisms) from all registered dossiers for the substance. The information provided in the free-text fields is not published in the Brief Profiles. Oxidation reduction potential in mV at 20°C provides substance information on the substance’s oxidation reduction measured in millivolts at a temperature of 20°C. The REACH regulatory processes identified for the Brief Profile are: Persistent Organic Pollutants (POPs)The POPs Regulation (EU) 2019/1021 entered into force on 15 July 2019, repealing the previous POPs Regulation (EC) No 850/2004. Short-term EC50 or LC50 for birds provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of birds in the test, generally displayed in milligram per kilo food. PIC administers the import and export of certain hazardous chemicals and places obligations on companies who wish to export these chemicals to non-EU countries. If only waived data is available for the substance, following justifications for data-waiving can be displayed in the Brief Profile: Some endpoints are not included in the Brief Profile due to the use of free text and/or complex field(s) in the reporting of information, which cannot be easily summarised by an automatic algorithm. Registrants can report substance information on viscosity as: Static viscosity at 20°C provides substance information on the substance’s (static) viscosity per square millimetre per second at a temperature of 20°C. Long-term EC10 or LC10 or NOEC for terrestrial plants provides substance information on the substance’s effect concentration or lethal concentration (long term) for 10% of the terrestrial plants in the test, or the no observed effect concentration for terrestrial plants. Half-life for hydrolysis provides substance information on the substance’s half-life for hydrolysis in seconds/minutes/hours/days/weeks/months/years at a temperature measured in °C.Note: Results without a measurement condition (temperature) are not processed for the Brief Profile. Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. This section summarises the Ecotoxicological information provided from all registered dossiers for the substance. Values are generally displayed in milligram per litre. Information in the ‘Scientific properties’ section is structured by substance properties, further broken down into endpoints. Please see the registered dossiers for substance information for the following endpoints: The ’Substance identity’ section links substance identification information from all databases that are maintained by ECHA. Guidance on the safe use of the substance provided by manufacturers and importers of this substance. Impurities or additives: When a specific critical property is associated with compositions with impurities and/or additives, the respective critical property icon has a * associated. In most cases, impurities constitute less than 10% of the substance. The quality and correctness of the information remains the responsibility of the data submitter. If so, the data provided is not processed for the Brief Profile. Data is generally displayed in milligram per litre or molar per litre. Short-term EC50 or LC50 for soil dwelling arthropods provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of the soil dwelling arthropods in the test, generally displayed in milligram per kilo soil (dry weight). 1), Substances or mixtures which in contact with water release flammable gases which may ignite spontaneously (Cat.1), Self-heating substances and mixtures (Cat.2), Substances or mixtures which in contact with water release flammable gases which may ignite spontaneously (Cat.2), Substances or mixtures which in contact with water releases flammable gases (Cat.3), Substances and mixtures which in contact with water emit flammable gases, Contact with water liberates highly flammable gases, Spontaneously flammable in air (pyrophoric), Projection hazard but not a mass explosion hazard (Div. Molecular Weight 116.07 . machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use. level’ as the dose descriptor. Processable data for study results is prioritised by dose descriptor type (see list below) and subsequently further prioritised by the test species. Dissociating Properties provides substance information by picklist values: Dissociation Constant provides numerical substance information on the substance’s dissociation constant values at a temperature measured in °C. Values are generally displayed in milligram per kilo soil (dry weight). It may, for example, originate from the starting materials or be the result of secondary or incomplete reactions during the production process. This substance has an industrial use resulting in manufacture of another substance (use of intermediates). If so, the data provided is not processed for the Brief Profile. The ‘Regulatory context’ section provides an overview of the regulatory activities that are related to the substance. Dissipation half-life provides substance information on the substance’s dissipation half-life for the parent compound per second/minute/hour/day/week/month/year. If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).Relative density provides substance information on the relatively density (measurement units are not processed for relative density) at a temperature measured in Celsius (°C). Koc at 20°C provides substance information on the substance’s Koc adsorption at a temperature 20 °C. EC10 / LC10 or NOEC for marine fish provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater fish or the no observed effect concentration. If so, the data provided is not processed for the Brief Profile.Prioritization by test species: Processable data for the summary is prioritised by test species (see list below) and subsequently further prioritised by the dose descriptor. Less soluble in water than L-tartaric acid.pH of 0.1M aq soln: 2.0. All the source data on which the summaries on this page are based, is provided by industry and stored in the ECHA databases. Bulk density provides substance information on the bulk density in (kilo)grams per (centi)metre (cm/m) at a temperature measured in °C. The quality and correctness of the information remains the responsibility of the data submitter. The Index number for each substance is in the form of a digit sequence of the type ABC-RST-VW-Y. pKa 1 2.96; pKa 2 4.24. Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). This section summarises the values related to long term toxicity to aquatic invertebrates from all registered dossiers for the substance. U.S. Patent US4772674, issued September, 1980. This section summarises the values related to aquatic/sediment bioaccumulation in all registered dossiers for the substance. The BPR addresses the placing on the market and use of biocidal products, which are used to protect humans, animals, materials or articles against harmful organisms, like pests or bacteria, by regulating the active substances contained in a biocidal product. Half-life in sediment provides substance information on the substance’s half-life in sediment in seconds/minutes/hours/days/weeks/months/years at a temperature measured in °C.Note: Results without a measurement condition (temperature) are not processed for the Brief Profile. Vigorous reaction in preliminary test plants from all registered dossiers for the substance performed: the precise data methods! 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